School of Medicine

Wayne State University School of Medicine

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Tomomi Ichinose
Assistant Professor
(313) 577-0836 (Office)
(313) 577-0837 (Lab)
 
Biography

Dr. Ichinose is a retinal neurophysiologist. Her research focuses on elucidating the function of the retinal neural network. Using patch clamp techniques, she has investigated how synaptic mechanisms, voltage-gated channels, GABA and glutamate transporters shape visual signaling in bipolar cells and ganglion cells in the retina. She has started her own laboratory since 2011, supported by NIH R01 grant. The goal of the project is to elucidate the cellular and molecular mechanisms of temporal visual information encoding in bipolar cells.

Education and Training

  • 1989 M.D. Hamamatsu University School of Medicine, Shizuoka, Japan
  • 1995 Ph.D. Tokyo Medical and Dental University, Tokyo, Japan

Professional Appointments and Licensures

  • 1989 Board Certified for Medicine (Japan)
  • 1995-2005 Board Certified Anesthesiologist (Japan)
  • 1995-2000 Assistant Professor, Nippon Medical School, Tokyo, Japan
  • 1998-2011 Staff Scientist, Washington University School of Medicine, St. Louis, MO
  • 2011-2012 Senior Scientist, Washington University School of Medicine, St. Louis, MO
  • 2012- current Assistant Professor, Wayne State University School of Medicine, Detroit, MI
     

 Research Educator, Full time, MD, Neuroscience

Publications

1. Ichinose T, Fyk-Kolodziej B, Cohn J: Roles of ON cone bipolar cell subtypes in temporal coding in the mouse retina. Journal of Neuroscience 34:8761-8771, 2014

2. Ichinose T, Lukasiewicz PD: The mode of retinal presynaptic inhibition switches with light intensity. Journal of Neuroscience 32:4360-4371, 2012

3. Ichinose T, Lukasiewicz PD: Light and dopamine regulate sodium channels to dynamically control retinal signaling. Journal of Neuroscience 27:4756-4764, 2007

4. Ichinose T, Lukasiewicz PD: Inner and outer retinal pathways both contribute to surround inhibition of salamander ganglion cells. Journal of Physiology 565 (Pt 2):517-35, 2005

5. Ichinose T, Shields CR, Lukasiewicz PD: Sodium channels in transient retinal bipolar cells enhance visual responses in ganglion cells. Journal of Neuroscience 25(7):1856-65, 2005

6. Ichinose T, Yu S, Wang XQ, Yu SP: Ca2+-independent, but voltage- and activity-dependent regulation of the NMDA receptor outward K+ current in mouse cortical neurons. Journal of Physiology 551(Pt 2):403-17, 2003

7. Ichinose T, Lukasiewicz PD: GABA transporters regulate inhibition in the retina by limiting GABA(C) receptor activation. Journal of Neuroscience 22(8):3285-92, 2002

8. Manzerra P, Behrens MM, Canzoniero LM, Wang XQ, Heidinger V, Ichinose T, Yu SP, Choi DW: Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity. Proceedings of the National Academy of Sciences U S A 98(20):11055-61, 2001

9. Ichinose T, Snider WD: Differential effects of TrkC isoforms on sensory axon outgrowth. Journal of Neuroscience Research 59(3):365-71, 2000