School of Medicine

Wayne State University School of Medicine

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Renu A. Kowluru
(313) 993-6714

Diabetic retinopathy is the leading cause of acquired blindness in young adults. The research focus is to understand the pathogenesis of this devastating disease which plagues over 80% of patients after 20 years of diabetes. We are also investigating the molecular and biochemical mechanisms responsible for the tendency of incipient retinopathy to continue after cessation of hyperglycemia-the Metabolic Memory phenomenon. Dr. Kowluru is the course coordinator for the Clinical and Basic Science Course in Ophthalmology-Bench to Bedside as well as a Course co-coordinator- ‘Biology of the Eye’. Dr. Kowluru was an Associate Scientist with the University of Wisconsin, Madison, WI.

Awards & Honors
  • Dennise L. Gierhart Charitable Award to support Diabetic Retinopathy Research, 2004
  • Mary Jane Kugel award from the Juvenile Diabetes Research Foundation, 2006
  • Faculty Research Excellence Award, School of Medicine, Wayne State University, 2007
  • Visiting Professor, University of Michigan, Ann Arbor, MI, 2008
  • Distinguished Diabetes Researcher, Harold Hamm Oklahoma Diabetes Center, Oklahoma City, OK, 2008
  • Distinguished Vision Faculty, Vision Discovery Institute, Medical College of Georgia, Augusta, GA, 2009


  • Editorial Board Member, Animal Physiology
  • Editorial Board member, Expert Opinion on Investigational Drugs, Ashley Publications, London,
  • Editorial Board Member, Investigative Ophthalmology & Visual Sciences
  • Editorial Board Member, International Journal of Biomedical Science
  • Editorial Board Member, International Journal of Diabetes Mellitus
  • Editorial Board Member, World Journal of Diabetes
  • Guest Editorial Board Member-Diabetes


  • Regular Member, Biology and Diseases of the Posterior Eye, National Eye Institute, 2006-2010
  • Regular Member, Research Grant Review Panel, Juvenile Diabetes Research Foundation, 2001---
  • Research Grant Reviewer, Wellcome Trust Foundation, 2002---
  • Grant Reviewer, Healy Foundation, Australia, 2003---
  • Kanwar M, Chan PS, Kern TS, Kowluru RA: Oxidative damage in the retinal mitochondria of diabetic mice: Possible protection by superoxide dismutase. Invest Ophthal Vis Sci 48: 3805-3811, 2007
  • Kowluru RA, Kanwar M, Chan PS, Zhang JP: Inhibition of retinopathy and retinal metabolic abnormalities in diabetic rats with AREDS-based micronutrients. Arch Ophthalmol 126:1266-1272, 2008
  • Kanwar M, Kowluru RA: Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy. Diabetes 58:227-234, 2009
  • Kowluru RA, Kanwar M: Oxidative stress and the development of diabetic retinopathy: Contributory role of matrix metalloproteinase-2. Free Rad Biol Med; 46:1677-1685, 2009
  • Kowluru RA, Kanwar M: Translocation of H-Ras and its implications in the development of diabetic retinopathy. Biochem Biophys Res Commun 387:461-466, 2009

    Pub Med