The major research focus of Dr. Braun's laboratory is the study of blood flow and oxygen transport in tumors, especially tumors growing in the eye. The ultimate goal is to modify tumor oxygenation and blood flow to improve the efficacy of existing treatments. Techniques used in the laboratory include measurement of blood flow with laser Doppler flowmetry, measurement of tissue oxygen levels using oxygen microelectrodes, and imaging of tumors with high frequency ultrasound. Recently, in collaboration with Dr. Berkowitz in the Department of Anatomy and Cell Biology, Dr. Braun has begun investigating the use of manganese as a functional MRI imaging tool in tumors.
Dr. Braun is Course Director of Medical Histology and Embryology, which is part of the Year 1 Medical School curriculum. He teaches a laboratory section and presents lectures in the course. In addition, he teaches the graduate student course in Histology, Microscopic Anatomy (ANA 7030). He also contributes individual lectures to the following graduate courses: Biology of the Eye (ANA 6050, 7055, PYC 7050, and BIO 6055, 7055) and Biomedical Cardiovascular, Respiratory, and Renal Systems Biology (IBS 7040).
Research Educator, Full time, PhD, Histology and Cell Biology, Embryology
- 1984, Pfizer Award (Outstanding Senior Chemical Engineering Student), Rose-Hulman Institute of Technology, Terre Haute, IN
- 1984-1985, General Electric Fellowship, Northwestern University, Evanston, IL
- 1986-1987, DAAD Scholarship (Deutscher Akademischer Austauschdienst), Universitat Mainz, Mainz, Germany, Laboratory of Dr. Peter Vaupel
- 1987-1988, Shell Fellowship, Northwestern University, Evanston, IL
- 1993-1996, National Research Service Award (NRSA) National Eye Institute, NIH, Duke University Eye Center, Durham, NC
- 2008-2009, Career Development Chair Award, Wayne State University, Detroit, MI
- Braun RD, Wienczewski CA, Abbas A: Erythrocyte flow in choriocapillaris of normal and diabetic rats. Microvasc. Res., 77: 247-255, 2009.
- Braun RD, Vistisen KS: Measurement of human choroidal melanoma xenograft volume in rats using high-frequency ultrasound. Invest. Ophthalmol. Vis. Sci., 49: 16-22, 2008.
- Braun RD, Gradianu M, Vistisen KS, Roberts RL, Berkowitz BA: Manganese-enhanced MRI of human choroidal melanoma xenografts. Invest Ophthalmol Vis Sci 48(3): 963-7, 2007.
- Braun RD, Beatty AL: Modeling of oxygen transport across tumor multicellular layers. Microvasc Res. 73(2):113-23, 2007.
- Braun RD, Abbas A: Orthotopic human choroidal melanoma xenografts in nude rats with aggressive and nonaggressive PAS staining patterns. Investigative Ophthalmology & Visual Science, 47: 7-16, 2006.