School of Medicine

Wayne State University School of Medicine

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Dennis J. Goebel
Associate Professor
(313) 577-8724

Dr. Goebel is a trained retinal neuroanatomist, whose work has made significant contribution to our current understanding of retinal neurocircuitry and function. Incorporating his biochemical/molecular training, Dr. Goebel has focused on the development of an in vivo retinal toxicity model that mimics damage produced by stroke. This model has allowed his lab to develop biochemical and cytochemical assays, in addition to anatomical assessments, that analytically monitor five distinct cell death pathways mediated by glutamate toxicity. Employment of this animal model has allowed for the characterization of putative neuroprotective compounds in a true in vivo system that are linked to Calcium/calmodulin-dependent protein kinase II and poly-ADP-ribose polymerase and the publishing of their results. More recently the model has led to the characterization of newly developed compounds designed to target unique binding domains of MAGUK intracellular scaffolding proteins that associate with the cytosolic domains of the NMDA or kainate ionotropic glutamate receptors and known cell death-mediating proteins such as nNos and CaMKII. These studies have evolved into a unique collaboration with research scientist at Brown University, Dartmouth University, the University of Michigan and the University of Rhode Island.

Dr. Goebel received his B.S. degree in Biology from Central Michigan University in 1978, an M..S. degree in Chemistry from Wayne State University in 1988 and then acquired his his Ph.D. in Anatomy & Cell Biology from Wayne State University in 1991. He served a two year postdoctorial fellowship in Cellular and Molecular Neurobiology at Sinai Hospital in the laboratory of Dr. Michael Bannon. Following his postdoctoral training, he rejoined the Dept. of Anatomy & Cell Biology at Wayne State University in 1994 and currently holds the title of Associate Professor.