The focus of Dr. Peduzzi's work is adult stem cells and their potential in the treatment of brain and spinal cord injuries and radiotherapy-induced brain damage. As an expert on adult stem cells, she has testified at the US Senate Committees on 3 different occasions on how autologous stem cells could revolutionize medicine. Using a person's own cells avoids the problems of rejection, tumor formation and ethical concerns. Adult stem cells from the olfactory mucosa located inside the nasal cavity have several advantages. This tissue can be obtained using minimally invasive methods and the normal fate of these stem cells is neurons. Her collaborators in Portugal found that this tissue caused functional improvement in people with chronic, severe spinal cord injury when combined with BIONT rehabilitation (Lima et al., 2010). Her studies in rats revealed that functional improvement only occurred when the olfactory stem cells were from rats that were identical genetically. These stem cells can be delivered into the cerebrospinal fluid that surrounds the brain and spinal cord using a routine medical procedure (spinal tap) to reach areas of damage. Olfactory mucosa stem cells may be the best method to treat any type of neural injury or disease. Rehabilitation in the form of exercise and environmental enrichment (Fischer & Peduzzi, 2007) is needed to reveal the potential of the stem cell treatment. If you would like more information about olfactory mucosal stem cells or would like to contribute to the efforts to bring this treatment to clinical trials, please click on the ASCENT (Adult Stem Cells Engineered for Neural Therapy) link below.
- Treasurer, Women in Neurotrauma, 1999-2001
- Pressbook Selection, 1997 Abstract for Society for Neuroscience
- Guest, President Bush's Speech on Cloning, White House, 2002
- Witness, US Senate Science, Technology, & Space Hearing Committee, 2003, 2004
- Member, Scientific Advisory Board, Neurorecovery Inc., 2004
- Witness, US Senate Committee on Appropriations, 2010
1. Peduzzi, J.D., T.B. Grayson, F.R. Fischer and E.E. Geisert, Jr. (1999) The expression of TAPA (CD81) correlates with the reactive response of astrocytes in the developing rat CNS. Exp. Neurol. 160:460-468. Medline
2. Bittner, G.D. T. Schallert, and J. D. Peduzzi. (2000) Degeneration, Trophic Interactions and Repair of Severed Axons: A Reconsideration of Some Common Assumptions, The Neuroscientist, 6: 88-110.
3. Meythaler, J.M, J.D. Peduzzi, and T.A. Novack. (2001) Current concepts: diffuse axonal injury associated traumatic brain injury. Archiv. Phys. Med. Rehab., 82:1461-1471. Medline
4. Jackson, C., C. Cobbs, J.D. Peduzzi, M. Novak, C. Morrow. (2001) Repetitive intrathecal injections of Poliovirus Replicons result in gene expression in neurons of the central nervous system without pathogenesis. Hum. Gene Ther. 12: 1827-1842. (cover photo) Medline
5. Woerly, S., V.D. Doan, F. Evans-Martin, C.G. Paramore, and J.D. Peduzzi. (2001) Spinal cord reconstruction using NeurogelTM and functional recovery after chronic injury. J. Neurosci. Research, 66:1187-1197. Medline
6. Morrow, C.D., M.T. Palmer, C. Jackson, L.K. Johansen, A. Bledsoe, D.C. Ansardi, D.C. Porter, C.S. Cobbs, and J.D. Peduzzi. Targeting of poliovirus replicons to neurons in the central nervous system. In Vector Targeting for Therapeutic Gene Delivery D.T. Curiel and J.T. Douglas (eds), Wiley Publishing, 2002.
7. Jackson, C.A., J. Messinger, M.S. Palmer, J.D. Peduzzi, and C. Morrow. (2003) Intramuscular inoculation of encapsidated or naked poliovirus replicons results in gene expression in the muscle and central nervous system. Virology. 314 (1): 45-61. (Cover photo) Medline
8. Jackson CA. Messinger J. Peduzzi JD. Ansardi DC. Morrow CD. (2005) Enhanced functional recovery from spinal cord injury following intrathecal or intramuscular administration of poliovirus replicons encoding IL-10. Virology. 336:173-83. (Cover photo) Medline
9. Lima, C., J. Pratas-Vital, P. Escada, A. Hasse-Ferreira, C. Capucho and J.D. Peduzzi. (2006) Olfactory mucosa autografts in human spinal cord injury a pilot clinical trial. J Spinal Cord Med. 29(3):191-203. Medline
10. Fischer, F.R. and J.D. Peduzzi. (2007). Functional Recovery in Rats with Chronic Spinal Cord Injuries after Exposure to an Enriched Environment. J. Spinal Cord Med. 30(2):147-155.
11. Lujan, H.L., G. Palani, Y. Chen, J.D. Peduzzi, S. E. DiCarlo. (2009) Targeted Ablation of Cardiac Sympathetic Neurons Reduces Resting, Reflex and Exercise-Induced Sympathetic Activation in Conscious Rats. Am J Physiol Heart Circ Physiol 296:H1305-H1311.
12. Hao, H-N., J.D. Peduzzi, P.J. VandeVord, K. Barami, S.P. DeSilva, D. Pedinkovic, L.G. Morawa. (2009) Lipopolysaccharide-induced inflammatory cytokine production by Schwann's cells dependent upon TLR4 expression. J. Neuroimmunology 212: 26-34.
13. Lujan, H.L., G. Palani, Y. Chen, J.D. Peduzzi, S. E. DiCarlo. (2009) Targeted Ablation of Mesenteric Projecting Sympathetic Neurons Reduces the Hemodynamic Response to Pain in Conscious Paraplegic Rats, Submitted American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 296:1305-1311.
14. Peduzzi, JD, C Lima, EM Haacke, E Dawe, B Semakula, J Jacobs, JP McAllister, K. Casey, J. Meythaler, (2010) MRI and Histochemical Localization of SPIO-Labeled Olfactory Mucosa Progenitor Cells Injected in the Cerebrospinal Fluid of Normal and Injured Rats And Pigs, J.Neurotrauma 27(5):A88.
15. Lima, C., P. Escada, J. Pratas-Vital, C. Branco, C.A. Arcangeli, G. Lazzeri, C.A.S. Maia, C. Capucho, A. Hasse-Ferreira, and J.D. Peduzzi (2010) Olfactory Mucosal Autografts and Rehabilitation for Chronic Traumatic Spinal Cord Injury. Neurorehab & Neural Repair 24:10-22.