School of Medicine

Wayne State University School of Medicine

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Ryan Thummel
Assistant Professor
(313) 577-7762
Biography

I joined the faculty at Wayne State University in 2009. My research focuses on retinal development and regeneration in zebrafish. Zebrafish is an attractive model to study neurodegenerative diseases due to its incredible ability to regenerate neuronal tissues. In particular, we are focused on better understanding the molecular mechanisms that underlie retinal regeneration in the adult zebrafish.

I participate in the teaching of Medical Histology and Medical Embryology to first year medical students. I find teaching and mentoring students very rewarding, especially training young scientists in the laboratory. If you are interested in joining the lab, please send me an email.

If you are interested in learning more about our research, please visit our lab website.

 

Awards & Honors
  • 2014 Session Co-Moderator, Annual Meeting for the International Society for Eye Research (ISER)
  • 2014 Invited speaker, Annual Meeting for the International Society for Eye Research (ISER)
  • 2014 Selected for Editorial Board, Journal of Visualized Experiments (JoVE)
  • 2013 Session Moderator, Annual Meeting for the Association for Research in Vision and Ophthalmology (ARVO)
  • 2013 First place award, 2013 Image Contest for Aquaneering, Inc.
  • 2012 Selected for Editorial Board, PLoS ONE
  • 2011 Selected for Editorial Board, The Scientific World Journal, Developmental Biology Domain
  • 2011 Session Moderator, Annual Meeting for the Association for Research in Vision and Ophthalmology (ARVO)
  • 2009 National Eye Institute, Stage 1 grant reviewer (2 grants)
  • 2008 Data presented in manuscript selected for cover image of journal. Dev. Neurobiol. (2008) 68 (3):392-408
  • 2008 National Science Foundation, Ad-hoc grant reviewer (1 grant)
  • 2008 Finalist, Outstanding Poster Presentation by a Postdoc, The 8th International Conference of Zebrafish Development and Genetics, University of Wisconsin
  • 2007 Recipient, Post-doctoral Fellowship, Fight for Sight Foundation
  • 2007 National Science Foundation, Ad-hoc grant reviewer (2 grants)
  • 2006 Finalist, Outstanding Poster Presentation by a Postdoc, The 7th International Conference on Zebrafish Development and Genetics, University of Wisconsin
  • 2004 Recipient, Postdoctoral Fellowship, Center for Zebrafish Research, University of Notre Dame
  • 2004 Defended Ph.D. Dissertation with Honors, Department of Molecular and Integrative Physiology, University of Kansas Medical Center
  • 2004 First Place, Oral Presentation, Student Research Forum, University of Kansas Medical Center
  • 2002 Recipient, Predoctoral Fellowship, Biomedical Training Grant, University of Kansas Medical Center
  • 2002 Semifinalist, Outstanding Poster Presentation by a Graduate Student, The 61st Annual Society for Developmental Biology Meeting, University of Wisconsin
  • 2002 First Place, Outstanding Poster Presentation by a Graduate Student, Midwest Developmental Biology Meeting, University of Missouri
  • 2001 Completed Ph.D. Qualifying Exam with Honors, Department of Molecular and Integrative Physiology, University of Kansas Medical Center
  • 2001 Second Place Presentation, Student Research Forum, University of Kansas Medical Center
  • 1998 Graduated Cum Laude, University of Notre Dame
  • 1994 Full Tuition Scholarship, Old College Program, University of Notre Dame
Publications

1. M. Shaw, P. Montgomery, R. Thummel, H. Tse. Identification of Two Immunogenic T Cell Epitopes of ApoB-100 and Their Autoimmune Implications. J. Immunol. Clin. Res. (2014) 2(2):1021.
2. J.L. Thomas and R. Thummel. A novel light damage paradigm for use in retinal regeneration studies in adult zebrafish. J. Vis. Exp. (2013) 80: e51017.
3. J.R. Lenkowski, Z Qin, C.J. Sifuentes, R. Thummel, C.M. Soto, C.B. Moens, P.A. Raymond. Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling. Glia. (2013) 61(10):1687-97.
4. J.L. Thomas, C.M. Nelson, X. Luo, D.R. Hyde, R. Thummel. Characterization of multiple light damage paradigms reveals regional differences in photoreceptor loss. Exp. Eye Res. (2012) 97(1): 106-16.
5. D.R. Hyde, A.R. Godwin, R. Thummel. In vivo electroporation of morpholinos into the regenerating adult zebrafish tail fin. J. Vis. Exp. (2012) 61:e3632.
6. J.L. Thomas, M.J. Ochocinska, P.F. Hitchcock, R. Thummel. Using the Tg(nrd:egfp)/albino zebrafish line to characterize in vivo expression of neurod. PLoS ONE (2012) 7(1): e29128.
7. R. Thummel, T.J. Bailey, D.R. Hyde. In vivo electroporation of morpholinos into the adult zebrafish retina. J. Vis. Exp. (2011) 58: e3603.
8. Z. Qin, A.R. Kidd III, J.L. Thomas, K.D. Poss, D.R. Hyde, P.A. Raymond, R. Thummel. FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish. Exp. Eye Res. (2011) 93(5): 726-34.
9. J.L. Thomas, T.S. Vihtelic, A.D. denDekker, G.B. Willer, X. Luo, T.R. Murphy, R.G. Gregg, D.R. Hyde, and R. Thummel. The loss of vacuolar protein sorting 11 (vps11) causes retinal pathogenesis in a vertebrate model of syndromic albinism. IOVS. (2011) 52(6): 3119-28.
10. R. Thummel, J.M. Enright, S.C. Kassen, J. E. Montgomery, T.J. Bailey, and D.R. Hyde. Pax6a and Pax6b are required at different points in neuronal progenitor cell proliferation during zebrafish photoreceptor regeneration. Exp. Eye Res. (2010) 90(5): 572-82.
11. S.E.L. Craig, R. Thummel, H. Ahmed, G.R. Vasta, D. R. Hyde, and P.F. Hitchcock. The zebrafish galectin Drgal1-L2 is expressed by proliferating Muller glia and photoreceptor progenitors and regulates the regeneration of rod photoreceptors. IOVS. (2010) 51(6): 3244-52.
12. S.C. Kassen, R. Thummel (co-first author), L.A. Campochiaro, M. J. Harding, N.A. Bennett, and David R. Hyde. CNTF induces photoreceptor neuroprotection and Müller glial cell proliferation through two different signaling pathways in the adult zebrafish retina. Exp. Eye Res. (2009) 88:1051-64.
13. S.C. Kassen, R. Thummel, C.T. Burket, L.A. Campochiaro, M.J. Harding, and D.R. Hyde. The Tg(cyclinB1:EGFP) transgenic zebrafish line is a marker for proliferation in retinal development and regeneration. Molecular Vision. (2008) 14:951-963.
14. R. Thummel, S.C. Kassen, J.M. Enright, C. M. Nelson, J.E. Montgomery, and D.R. Hyde. Characterization of Müller glia and neuronal progenitors in adult zebrafish retinal regeneration. Exp. Eye Res. (2008) 87 (5): 433-44.
15. A.D. Hoptak-Solga, S. Neilsen, I. Jain, R. Thummel, D.R. Hyde, and M.K. Iovine. Connexin43 (GJAI) is required for the initiation of cell proliferation during fin growth. Dev. Bio. (2008) 317 (2):541-8.
16. R. Thummel, S.C. Kassen, J. E. Montgomery, J.M. Enright, and D.R. Hyde. Inhibition of Müller glial cell division during retinal regeneration of the adult zebrafish retina. Dev. Neurobiol. (2008) 68 (3):392-408.
17. V.P. Yin, J.M. Thomson, R. Thummel, D.R. Hyde, S.M. Hammond, and K.D. Poss. Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish. Genes and Dev. (2008) 22: 728-733.
18. C.T. Burket, J. Montgomery, R. Thummel, S.C. Kassen, M. Lafave, D. Langaneau, L. Zon, and D.R. Hyde. Generation and characterization of transgenic zebrafish lines using different ubiquitous promoters. Transgenic Research. (2008) 17(2):265-279.
19. R. Thummel, M. Ju, M.P. Sarras Jr., A.R. Godwin. Both Hoxc13 orthologs are functionally important for zebrafish tail fin regeneration. Development Genes and Evolution (2007) 217 (6):413-20.
20. R. Thummel, C.T. Burket, and D.R. Hyde. Two different transgenes to study gene silencing and re-expression during zebrafish caudal fin and retinal regeneration. TSW Dev and Embryology (2006) 6:65-81.
21. R. Thummel, S. Bai, M.P. Sarras Jr., P. Song, J. McDermott, J. Brewer, M. Perry, X. Zhang, D.R. Hyde, A.R. Godwin. Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxb. Developmental Dynamics (2006) 235: 336-346.
22. S. Bai, R. Thummel, A.R. Godwin, H. Nagase, Y. Itoh, L. Li, R. Evans, J. McDermott, M. Seiki, and M.P. Sarras, Jr. Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2. Matrix Biology (2005) 24 (4):247-60.
23. R. Thummel, C.T. Burket, J. Brewer, M.P. Sarras, Jr., L. Li, M. Perry, J. McDermott, B. Sauer, D.R. Hyde, and A.R. Godwin. Cre-mediated site-specific recombination in zebrafish embryos. Developmental Dynamics (2005) 233 (4):1366-77.
24. R. Thummel, L. Li, C. Tanase, M.P. Sarras, Jr., and A.R. Godwin. Differences in expression pattern and function between zebrafish hoxc13 orthologs: Recruitment of Hoxc13b into an early embryonic role. Developmental Biology (2004) 274 (2): 318-333.