Michael Landowski
Office location
540 East Canfield
9304 Scott Hall
Detroit, MI 48201
Biography
Dysregulation of lipid metabolism is strongly associated with the development of outer retinal diseases including Stargardt’s disease and age-related macular degeneration. However, the regulation of lipid metabolism within the retina remains unclear and understudied. The Landowski laboratory uses a combination of mouse models, cell culture systems, and human samples to investigate key pathways involved in retinal lipid metabolism. In the long term, this work will add to our understanding of the complex nature of retinal lipid metabolism, providing insight into outer retinal disease pathogenesis and generating novel therapeutic targets for preventing the vision loss occurring in patients with these diseases.
Education
Ph.D., Duke University (Genetics and Genomics)
B.S., University of Wisconsin-Madison (Genetics)
Publications
Selected publications
Landowski M, Ikeda S, Ikeda A. Association between C22:5-containing Lipids and RPE Pathologies
in Mice with Tmem135 Overexpression. Adv Exp Med Biol, 2025 Feb; 1468: 207-212. PMID: 39930197.
Landowski M, Gogoi P, Ikeda S, Ikeda A. Roles of transmembrane protein 135 in mitochondrial and peroxisomal functions – implications for age-related retinal disease. Front Ophthalmol (Lausanne), 2024 Jan 30, (4). PMID: 38576540.
Landowski M, Grindel S, Hao Y, Ikeda S, Bowes Rickman C, Ikeda A. A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration. J Vis Exp, 2023 Mar 10, (193). PMID: 36971449.
Landowski M, Bhute VJ, Grindel S, Haugstad Z, Gyening YK, Tytanic M, Brush RS, Moyer LJ, Nelson DW, Davis CR, Yen CE, Ikeda S, Agbaga MP, Ikeda A. Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism. Commun Biol, 2023 Jan 4, 6(1):8. PMID: 36599953.
Landowski M*, Bhute VJ*, Takimoto T, Grindel S, Shahi PK, Pattnaik BR, Ikeda S, Ikeda A. A Mutation in Transmembrane protein 135 Impairs Lipid Metabolism in Mouse Eyecups. Sci Rep, 2022 Jan 14, 12(1): 756. PMID: 35031662.
Landowski M, Grindel S, Shahi PK, Johnson A, Western D, Race A, Shi F, Benson J, Gao M, Santoirre E, Lee WH, Ikeda S, Pattnaik BR, Ikeda A (2020) Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice. Invest Ophthalmol Vis Sci, 2020 Oct 1, 61(12):16. PMID: 33064130.
Kelly UL, Grigsby D, Cady MA, Landowski M, Skiba NP, Liu J, Remaley AT, Klingeborn M, Bowes Rickman C. High Density Lipoproteins are a Potential Therapeutic Target for Age-related Macular Degeneration. J Biol Chem, 2020 Sep 25, 295(39):13601-13616. PMID: 32737203.
Landowski M, Kelly U, Klingeborn M, Groelle M, Ding JD, Grigsby D, Bowes Rickman, C. Human Complement Factor H Y402H Polymorphism Causes an Age-related Macular Degeneration Phenotype and Lipoprotein Dysregulation in Mice. PNAS, 2019 Feb 26, 116(9):3703-3711. PMID: 30808757.
Toomey CB*, Landowski M*, Klingeborn M, Kelly U, Deans J, Dong H, Harrabi O, Van Blarcom T, Yeung YA, Grishanin R, Lin JC, Saban DR, Bowes Rickman C. Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci, 2018 Feb 1, 59(2):662-673. PMID: 29392311.
Ding JD, Kelly U, Landowski M, Toomey CB, Groelle M, Miller C, Smith SG, Klingeborn M, Singhapricha T, Jiang H, Frank MM, Bowes Rickman C. Expression of human complement factor H prevents age-related macular degeneration-like retinal damage and kidney abnormalities in aged Cfh knockout mice. Am J Pathol, 2015 Jan, 185(1):29-42. PMID: 25447048.
* denotes shared first authorship.