Tomomi Ichinose, M.D.
Tomomi Ichinose, M.D.
Laboratory Web Site
Position TitleAssistant Professor
Office Phone(313) 577-0836 (Office) (313) 577-0837 (Lab)
Dr. Ichinose’s research is focused on the function of the retinal neural network. Using patch clamp techniques together with morphological and molecular biological methods, we have examined the unique features of each bipolar cell type in the mouse retina. Bipolar cells are second-order neurons in the retina that receive synaptic inputs from photoreceptors and are thought to initiate visual feature-oriented, parallel processing pathways. We found that a subset of bipolar cells (types 2, 3, 5-2, XBC, 7) respond transiently to a step of light and exhibit high frequency tuning to a sinusoidal light stimuli, whereas other bipolar cells (types 1, 4, 5-1, 8) respond to a step of light in a sustained fashion and tune to low frequency stimuli (Figure). We found that voltage-gated channels shaped the distinct responses, including voltage-gated Na+ channels that were found in some transiently responding cells (Types 3a, 5-2, XBC). In addition, we found that dopamine 1 receptors (Drd1a) are expressed by a subset of bipolar cells in a type-dependent manner. These results suggest that distinct features of visual signaling are coded to separate types of bipolar cells, such as motion and color. Future directions that we plan to pursue include investigating temporal tuning by dopaminergic signaling in bipolar cells and bipolar cell-ganglion cell synaptic connections and signaling.
Dr. Ichinose teaches neuroanatomy for MD1 and PhD as a member of MD1_Neurosciences Faculty (MD1_5600_1607_001_701_67). She also teaches Retinal Neurophysiology and Central Visual Pathways for Biology of the Eye course (ANA 6050, 7055, Bio 6055, 7055).
Research Educator, Full time, MD, Neuroscience
- 1989 M.D. Hamamatsu University School of Medicine, Shizuoka, Japan
- 1995 Ph.D. Tokyo Medical and Dental University, Tokyo, Japan
- 1995 Board Certified Anesthesiologist Japan
Professional Appointments and Licensures
- 1989 Board Certified for Medicine (Japan)
- 1995-2005 Board Certified Anesthesiologist (Japan)
- 1995-2000 Assistant Professor, Nippon Medical School, Tokyo, Japan
- 1998-2011 Staff Scientist, Washington University School of Medicine, St. Louis, MO
- 2011-2012 Senior Scientist, Washington University School of Medicine, St. Louis, MO
- 2012- Assistant Professor, Wayne State University School of Medicine, Detroit, MI
Links of Interest
- Ichinose T, Hellmer CH: Differential signaling and glutamate receptor compositions in the OFF bipolar cell types in the mouse retina. Journal of Physiology 594(4):883-94, 2016. PMCID: PMC4753269 Corresponding Author
- Farshi P, Fyk-Kolodziej B, Krolewski DM, Walker PD, Ichinose T.: Dopamine D1 receptor expression is bipolar cell type-specific in the mouse retina. Journal of Comparative Neurology 524(10):2059-79, 2016. PMCID: PMC4860096 Corresponding Author
- Hellmer,CB, Zhou Y, Fyk-Kolodziej B, Hu Z, Ichinose T.: Morphological and physiological analysis of type-5 and other bipolar cells in the mouse retina. Neuroscience 315:246-58, 2016. PMCID: PMC4715942 Corresponding Author
- Hellmer CH, Ichinose T: Recording light-evoked postsynaptic responses in neurons in dark-adapted, mouse retinal slice preparations using patch clamp techniques. Journal of Visualized Experiments (JoVE) Feb 11;(96), 2015. PMCID: PMC4354633 Corresponding Author
- Ichinose T, Fyk-Kolodziej B, Cohn J: Roles of ON cone bipolar cell subtypes in temporal coding in the mouse retina. Journal of Neuroscience 34:8761-8771, 2014
- Ichinose T, Lukasiewicz PD: The mode of retinal presynaptic inhibition switches with light intensity. Journal of Neuroscience 32:4360-4371, 2012
- Ichinose T, Lukasiewicz PD: Light and dopamine regulate sodium channels to dynamically control retinal signaling. Journal of Neuroscience 27:4756-4764, 2007
- Ichinose T, Lukasiewicz PD: Inner and outer retinal pathways both contribute to surround inhibition of salamander ganglion cells. Journal of Physiology 565 (Pt 2):517-35, 2005
- Ichinose T, Shields CR, Lukasiewicz PD: Sodium channels in transient retinal bipolar cells enhance visual responses in ganglion cells. Journal of Neuroscience 25(7):1856-65, 2005
- Ichinose T, Yu S, Wang XQ, Yu SP: Ca2+-independent, but voltage- and activity-dependent regulation of the NMDA receptor outward K+ current in mouse cortical neurons. Journal of Physiology 551(Pt 2):403-17, 2003
- Ichinose T, Lukasiewicz PD: GABA transporters regulate inhibition in the retina by limiting GABA(C) receptor activation. Journal of Neuroscience 22(8):3285-92, 2002
- Manzerra P, Behrens MM, Canzoniero LM, Wang XQ, Heidinger V, Ichinose T, Yu SP, Choi DW: Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity. Proceedings of the National Academy of Sciences U S A 98(20):11055-61, 2001
- Ichinose T, Snider WD: Differential effects of TrkC isoforms on sensory axon outgrowth. Journal of Neuroscience Research 59(3):365-71, 2000