Tomomi Ichinose

Tomomi Ichinose

Tomomi Ichinose

Laboratory Web Site

Ichinose Lab

Position Title


Office Location

Scott Hall Room 8314

Office Phone

(313) 577-0836 (Office) (313) 577-0837 (Lab)


Dr. Ichinose’s laboratory focuses on the elucidation of retinal neural networks. When light illuminates the eyes, photoreceptors capture the visual inputs and convert them to neural signals. Retinal bipolar cells, horizontal cells, amacrine cells, and ganglion cells form neural networks to extract specific components of visual inputs, such as color and motion. Then, each signal is sent to the brain in parallel. We recently focused on the motion detection pathway and showed that the acetylcholine feedback pathway to bipolar cells contributes to the direction selectivity in ganglion cells. We also focus on the ON and OFF signaling pathways and their interactions.

The retinal neural network is complicated because of numerous subsets of neurons. We utilize patch clamp recordings, two-photon calcium imaging, immunohistochemistry, molecular biology, and mouse behavioral methods to solve mechanisms of visual signal processing. We expect that our study will contribute to understanding retinal diseases and fabrications of artificial retinas.

Dr. Ichinose teaches neuroanatomy for MD1 as a member of the MD1_Neurosciences Faculty (MD1_5600_1607_001_701_67) and as the Course Director for the Graduate Neuroanatomy (ANA 7130). She also teaches Retinal Neurophysiology and Central Visual Pathways for Biology of the Eye course (ANA 6050, 7055, Bio 6055, 7055).

Research Educator, Full time, MD, Neuroscience



  • 1989 M.D. Hamamatsu University School of Medicine, Shizuoka, Japan
  • 1995 Ph.D. Tokyo Medical and Dental University, Tokyo, Japan
  • 1995 Board Certified Anesthesiologist Japan

Faculty Appointments

Professional Appointments and Licensures

  • 1989 Board Certified for Medicine (Japan)
  • 1995-2005 Board Certified Anesthesiologist (Japan)
  • 1995-2000 Assistant Professor, Nippon Medical School, Tokyo, Japan
  • 1998-2011 Staff Scientist, Washington University School of Medicine, St. Louis, MO
  • 2011-2012 Senior Scientist, Washington University School of Medicine, St. Louis, MO
  • 2012-2019  Assistant Professor, Wayne State University School of Medicine, Detroit, MI
  • 2019-2023  Associate Professor, Wayne State University School of Medicine, Detroit, MI
  • 2023-Present  Professor, Wayne State University School of Medicie, Detroit, MI


 NIH/NEI R01 EY028915, EY032917

Areas of Research

 Visual Neuroscience, Neurophysiology, and imaging.

Links of Interest

Kresge Eye Institute


  • Bohl JM, Gope J, Sharpe ZJ, Shehu A, Garrett A, Koehler CC, Hellmer CB, Ichinose T. Off starburst amacrine cells in the retina trigger looking-evoked fear responss in mice. eNeuro 2023 Apr 11:10(4)
  • Ichinose T, Hellmer CB, Bohl JM. Presynaptic depolarization differentially regulates dual neurotranmitter releae from starburst amacrine cells in the mouse retina. Front. Ophthalmol. 3:1225824, 2023
  • Sharpe ZJ, Shehu A, Ichinose T. Asymmetric Distributions of Achromatic Bipolar Cells in the Mouse Retina. Front Neuroanatomy 2022 Jan 13;15:786142.
  • Bohl JM, Shehu A, Hellmer CB, Ichinose T. Patch clamp recording from bipolar cells in the wholemount mouse retina. STAR Protocol 2022 Jun 17:3(3):101482
  • Ichinose T, Habib S. ON and OFF signaling pathways in the retina and the visual system. Front Ophthalmol. 2022 Aug 26; 989002
  • Hellmer CB, Hall LM, Bohl JM, Sharpe ZJ, Smith RG, Ichinose T. Cholinergic feedback to bipolar cells contributes to motion detection in the mouse retina. Cell Reports 2021 Dec 14;37(11):110106
  • Hellmer CB, Bohl JM, Hall LM, Koehler CC, Ichinose T. Dopaminergic Modulation of Signal Processing in a Subset of Retinal Bipolar Cells. Front Cell Neurosci. 2020 Aug 14;14:253.
  • Hall LM, Hellmer CB, Koehler CC, Ichinose T. Bipolar Cell Type-Specific Expression and Conductance of Alpha-7 Nicotinic Acetylcholine Receptors in the Mouse Retina. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1353-1361
  • Koehler CC, Hall LM, Hellmer CB, Ichinose T. Using Looming Visual Stimuli to Evaluate Mouse Vision. J Vis Exp. 2019 Jun 13;(148).
  • Wang Y, Hall LM, Kujawa M, Li H, Zhang X, O'Meara M, Ichinose T, Wang JM. Methylglyoxal Triggers Human Aortic Endothelial Cell Dysfunction via Modulating KATP/MAPK pathway. Am J Physiol Cell Physiol. 2019 Apr 17.
  • Hellmer CB, Clemons MR, Nawy S, Ichinose T. A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina. Physiol Rep. 2018 Oct;6(20):e13885. doi: 10.14814/phy2.13885.
  • Hellmer CB, Ichinose T. Functional and Morphological Analysis of OFF Bipolar Cells. Methods Mol Biol. 2018;1753:217-233. doi: 10.1007/978-1-4939-7720-8_15.
  • Ichinose T, Hellmer CH: Differential signaling and glutamate receptor compositions in the OFF bipolar cell types in the mouse retina. Journal of Physiology 594(4):883-94, 2016. PMCID: PMC4753269 Corresponding Author
  • Farshi P, Fyk-Kolodziej B, Krolewski DM, Walker PD, Ichinose T.: Dopamine D1 receptor expression is bipolar cell type-specific in the mouse retina. Journal of Comparative Neurology 524(10):2059-79, 2016. PMCID: PMC4860096 Corresponding Author
  • Hellmer,CB, Zhou Y, Fyk-Kolodziej B, Hu Z, Ichinose T.: Morphological and physiological analysis of type-5 and other bipolar cells in the mouse retina. Neuroscience 315:246-58, 2016. PMCID: PMC4715942 Corresponding Author
  • Hellmer CH, Ichinose T: Recording light-evoked postsynaptic responses in neurons in dark-adapted, mouse retinal slice preparations using patch clamp techniques. Journal of Visualized Experiments (JoVE) Feb 11;(96), 2015. PMCID: PMC4354633 Corresponding Author
  • Ichinose T, Fyk-Kolodziej B, Cohn J: Roles of ON cone bipolar cell subtypes in temporal coding in the mouse retina. Journal of Neuroscience 34:8761-8771, 2014
  • Ichinose T, Lukasiewicz PD: The mode of retinal presynaptic inhibition switches with light intensity. Journal of Neuroscience 32:4360-4371, 2012
  • Ichinose T, Lukasiewicz PD: Light and dopamine regulate sodium channels to dynamically control retinal signaling. Journal of Neuroscience 27:4756-4764, 2007
  • Ichinose T, Lukasiewicz PD: Inner and outer retinal pathways both contribute to surround inhibition of salamander ganglion cells. Journal of Physiology 565 (Pt 2):517-35, 2005
  • Ichinose T, Shields CR, Lukasiewicz PD: Sodium channels in transient retinal bipolar cells enhance visual responses in ganglion cells. Journal of Neuroscience 25(7):1856-65, 2005
  • Ichinose T, Yu S, Wang XQ, Yu SP: Ca2+-independent, but voltage- and activity-dependent regulation of the NMDA receptor outward K+ current in mouse cortical neurons. Journal of Physiology 551(Pt 2):403-17, 2003
  • Ichinose T, Lukasiewicz PD: GABA transporters regulate inhibition in the retina by limiting GABA(C) receptor activation. Journal of Neuroscience 22(8):3285-92, 2002
  • Manzerra P, Behrens MM, Canzoniero LM, Wang XQ, Heidinger V, Ichinose T, Yu SP, Choi DW: Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity. Proceedings of the National Academy of Sciences U S A 98(20):11055-61, 2001
  • Ichinose T, Snider WD: Differential effects of TrkC isoforms on sensory axon outgrowth. Journal of Neuroscience Research 59(3):365-71, 2000 

PubMed Link


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