Ahmed Ibrahim
Position Title
Assistant Professor
Joint appointed: Ophthalmology, Visual and Anatomical Sciences and Pharmacology
Biography
My research centers on investigating the underlying molecular and cellular mechanisms of Angiogenesis-driven diseases. The focus is primarily on pathological ocular angiogenesis which is the underlying mechanism of a variety of sight-threatening diseases such as Retinopathy of prematurity (ROP), proliferative diabetic retinopathy (PDR), and exudative age-related macular degeneration (wet AMD). Vision loss in these diseases begins in a common biphasic process characterized by initial loss of the preexisting vessel bed followed by hypoxia that triggers a secondary aberrant angiogenesis. The introduction of Anti-VEGF drugs has revolutionized the treatment of these diseases; however, a significant subset of patients fail to respond. Therefore, inhibition of only VEGF may not be sufficient, and alternative therapies with non-VEGF targets are urgently needed. The long-term goal of my research is to identify such novel therapeutic targets, with specific focus on endothelial metabolic reprogramming, and to discover already FDA-approved drug(s) that could be repurposed to modulate the key proteins in the energy metabolism of angiogenic endothelial cells.
Education
Bachelor of Pharmacy, (BSc. Pharm, Hons.), 2002; M.Sc. in Pharmaceutical Sciences, 2006; Ph.D in Pharmaceutical Sciences, 2011.
Publications
Peer-Reviewed Publications - Reports of Original Work Articles
- Elmarakby AA, Ibrahim AS, Katary MA#, Elsherbiny NM#, El-Shafey M#, Abd-Elrazik AM, Abdelsayed RA, Maddipati KR, Al-Shabrawey M: A dual role of 12/15-lipoxygenase in LPS-induced acute renal inflammation and injury. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2019; (Impact Factor (IF)= 4.4).
- Valle ML, Dworshak J, Sharma A, Ibrahim AS, Al-Shabrawey M, Sharma S: Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells. Experimental eye research 2019, 178:27-36; (IF=3.0, cited 2 times).
- Ibrahim AS, Elmasry K, Wan M, Abdulmoneim S, Still A, Khan F, Khalil A, Saul A, Hoda MN, Al-Shabrawey M: A Controlled Impact of Optic Nerve as a New Model of Traumatic Optic Neuropathy in Mouse. Investigative ophthalmology & visual science 2018, 59:5548-57; (IF= 3.8).
- Elmasry K, Ibrahim AS, Saleh H, Elsherbiny N, Elshafey S, Hussein KA, Al-Shabrawey M. Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy. Diabetologia. 2018 Feb 21 (IF=7.13).
- Ibrahim AS, Saleh H, El-Shafey M, Hussein KA, El-Masry K#, Baban B, Sheibani N, Wang MH, Tawfik A and Al-Shabrawey M. Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis. Biochimica Et Biophysica Acta-Molecular And Cell Biology of Lipids; 2017 Jun;1862(6):636-645 (IF)=4.40.
- Mohamed R, Sharma I, Ibrahim AS, Saleh H, Elsherbiny NM, Fulzele S, Elmasry K, Smith SB, Al-Shabrawey M, Tawfik A. Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress. Sci Rep. 2017 Sep 20;7(1):11952, (IF=4.01).
- Elimam DM#, Ibrahim AS, Liou GI, Badria FA.Olive and ginkgo extracts as potential cataract therapy with differential inhibitory activity on aldose reductase. Drug Discov Ther; 2017 Mar 22;11(1):41-46.
- Samra YA#, Saleh H, Hussein KA, Elsherbiny NM, Ibrahim AS, Elmasry K, Fulzele S, El-Shishtawy MM, Eissa LA, Al-Shabrawey M, Liou GI. Adenosine Deaminase-2–induced hyperpermeability in human retinal vascular endothelial cells is suppressed by microRNA-146b-3p. IOVS; 2017 Feb 1;58(2):933-943 (IF= 3.8).
- Elkhateeb SR#, Gouda NS, Ibrahim AS, Anwar R, Eissa LA. PCR-detected fungal infection is associated with fatal outcomes in cirrhotic patients with spontaneous peritonitis. Egyptian Journal of Basic and Applied Sciences. 2017 March, Volume 4, Issue 1, Pages 42–46.
- Ibrahim AS, Mander S, Hussein KA, Elsherbiny NM, Smith SB, Al-Shabrawey M, Tawfik A. Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration. Oncotarget-Geriatric Journal. 2016 Feb 23;7(8):8532-45 (IF= 5.2; cited 8 times).